Pharmacokinetic-Pharmacodynamic Modeling and Simulation [Kindle Edition] Author: | Language: English | ISBN:
B008CNO5GC | Format: PDF, EPUB
Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Free download Pharmacokinetic-Pharmacodynamic Modeling and Simulation [Kindle Edition] from 4shared, mediafire, hotfile, and mirror link This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated. Direct download links available for Pharmacokinetic-Pharmacodynamic Modeling and Simulation
- File Size: 17515 KB
- Print Length: 650 pages
- Publisher: Springer US; 2 edition (July 1, 2011)
- Sold by: Amazon Digital Services, Inc.
- Language: English
- ASIN: B008CNO5GC
- Text-to-Speech: Enabled
X-Ray:
- Lending: Not Enabled
- Amazon Best Sellers Rank: #302,410 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
- #66 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Medical eBooks > Pharmacology > Pharmacy
I have been teaching modeling and simulation for several years. By itself, Chapter 1: "The Art of Modeling", is simply an excellent overview of the topic; and not only applies to pharmacokinetic-pharmacodynamic modeling, but to modeling in general. It covers the usual suspects: what is a model, types of models, properties of a useful model, model development process, goodness-of-fit criteria and metrics, and model validation. Furthermore, gives a good introduction to subtle but important topics, such as: model discrimination criteria (AIC, F-test, etc.), identifiability of compartmental models, importance of effective communication and ethics in modeling. I have not gone through the details in all the other chapters, but given my good impression based in Chapter 1, I am sure that this textbook will become a must read to any serious modeler in the field of pharmacokinetic-pharmacodynamic.
By C. Gelmi
This is a remarkable book - a single-author monograph covering a difficult and large field. Dr Bonate has the industry experience to write authoritatively about real problems in PK/PD modeling, and includes a few valuable examples that delve deeply into the problems that will be encountered in real projects. Overall, I recommend this to anyone willing to do the work to read it.
Complaints are minor, and feel a bit unfair to even mention. Firstly, the book could have used an editor. A few sections are a bit off-topic (for example, a tour of ECGs with misinformation about lead nomenclature, multiple typos and some grammatical errors/imprecision, use of abbreviations before they are defined (common with cut/paste during revision), and an absolutely dreadful index - typical of modern-day books in the technical medical arena - use the ToC to find things instead. Dr Bonate has a spectacular grasp of mathematics compared with this reviewer (an MD and physicist by background) - very few medical people will be able to keep up with the theoretical presentations. Statisticians will probably be ok with the assumed knowledge base, PK people perhaps... But he makes a good effort at helping guide the reader, if diligent, through arcana and traps alike, freely offering very valuable tips and rules of thumb of the sort that can only be gleaned by suffering through simulations and fittings. I would have appreciated a few more simple examples first, before delving into things like 'Generation of Weibull Random Variates', just to pull a (random) example - but for advanced practitioners, the deep-dives may be the most valuable aspect.
I personally found the book interesting enough to read it cover to cover, and appreciated the human touch in the Preface that captured some of the immense effort this must have been to complete. In summary, for anyone really serious about trying to understand and contribute to PK/PD analysis, this is an excellent book to own and consult frequently.
By Richard Reeves
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