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Friday, May 31, 2013

An Anatomy of Addiction


An Anatomy of Addiction: Sigmund Freud, William Halsted, and the Miracle Drug Cocaine [Kindle Edition]

Author: Howard Markel | Language: English | ISBN: B004J4WJXE | Format: PDF, EPUB

An Anatomy of Addiction: Sigmund Freud, William Halsted, and the Miracle Drug Cocaine
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From acclaimed medical historian Howard Markel, author of When Germs Travel, the astonishing account of the years-long cocaine use of Sigmund Freud, young, ambitious neurologist, and William Halsted, the equally young, pathfinding surgeon. Markel writes of the physical and emotional damage caused by the then-heralded wonder drug, and how each man ultimately changed the world in spite of it—or because of it. One became the father of psychoanalysis; the other, of modern surgery.
 
Both men were practicing medicine at the same time in the 1880s: Freud at the Vienna General Hospital, Halsted at New York’s Bellevue Hospital. Markel writes that Freud began to experiment with cocaine as a way of studying its therapeutic uses—as an antidote for the overprescribed morphine, which had made addicts of so many, and as a treatment for depression.
 
Halsted, an acclaimed surgeon even then, was curious about cocaine’s effectiveness as an anesthetic and injected the drug into his arm to prove his theory. Neither Freud nor Halsted, nor their colleagues, had any idea of the drug’s potential to dominate and endanger their lives. Addiction as a bona fide medical diagnosis didn’t even exist in the elite medical circles they inhabited.
 
In An Anatomy of Addiction, Markel writes about the life and work of each man, showing how each came to know about cocaine; how Freud found that the drug cured his indigestion, dulled his aches, and relieved his depression. The author writes that Freud, after a few months of taking the magical drug, published a treatise on it, Über Coca, in which he described his “most gorgeous excitement.” The paper marked a major shift in Freud’s work: he turned from studying the anatomy of the brain to exploring the human psyche.
 
Halsted, one of the most revered of American surgeons, became the head of surgery at the newly built Johns Hopkins Hospital and then professor of surgery, the hospital’s most exalted position, committing himself repeatedly to Butler Hospital, an insane asylum, to withdraw from his out-of control cocaine use.
 
Halsted invented modern surgery as we know it today: devising new ways to safely invade the body in search of cures and pioneering modern surgical techniques that controlled bleeding and promoted healing. He insisted on thorough hand washing, on scrub-downs and whites for doctors and nurses, on sterility in the operating room—even inventing the surgical glove, which he designed and had the Goodyear Rubber Company make for him—accomplishing all of this as he struggled to conquer his unyielding desire for cocaine.
 
An Anatomy of Addiction tells the tragic and heroic story of each man, accidentally struck down in his prime by an insidious malady: tragic because of the time, relationships, and health cocaine forced each to squander; heroic in the intense battle each man waged to overcome his affliction as he conquered his own world with his visionary healing gifts. Here is the full story, long overlooked, told in its rich historical context.




From the Hardcover edition. Download latest books on mediafire and other links compilation An Anatomy of Addiction: Sigmund Freud, William Halsted, and the Miracle Drug Cocaine [Kindle Edition]
  • File Size: 4669 KB
  • Print Length: 352 pages
  • Publisher: Vintage; 1 edition (July 19, 2011)
  • Sold by: Random House LLC
  • Language: English
  • ASIN: B004J4WJXE
  • Text-to-Speech: Enabled
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  • Lending: Not Enabled
  • Amazon Best Sellers Rank: #178,403 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
    • #10 in Books > Biographies & Memoirs > People, A-Z > ( F ) > Freud, Sigmund
    • #65 in Kindle Store > Kindle eBooks > Nonfiction > Professional & Technical > Medical eBooks > Special Topics > History
In Howard Markel's "An Anatomy of Addiction," two renowned figures are attracted to "a miracle drug" that reduced appetite and the need for sleep, sharpened one's focus, relieved depression, and induced a feeling of euphoria. It also had anesthetic properties that could be useful for surgeons performing dental or ophthalmological procedures. Both Sigmund Freud, the pioneering psychoanalyst, and William Halsted, one of the greatest surgeons of his time, were fascinated by this drug and decided to try it out on themselves. As a result, both became addicted to cocaine.

Dr. Markel's command of his subject is impressive; his excellent source materials include letters, journal articles, and monographs. The author provides enlightening background information about medical practice in the nineteenth century, especially in the United States and Vienna. He vividly describes Bellevue Hospital in New York City, Johns Hopkins in Baltimore, and the Allgemeines Krankenhaus in Vienna, large complexes that were bursting at the seams with both affluent and indigent patients. Young physicians-in-training flocked to these institutions to learn from more experienced and skilled medical practitioners.

It is fascinating to learn how naïve people were concerning cocaine's short and long-term effects. The same could be said of opium, morphine, and laudanum, all of which were dispensed liberally to treat a host of complaints. No one understood the underlying nature of addiction. There were no "rehabs." If someone were unfortunate enough to become dependent on a drug, he or she would have a very difficult time breaking the habit. Freud and Halsted were particularly susceptible to this disease because of who they were.
Both Sigmund Freud, father of psychoanalysis, and William Halsted, originator of modern surgery, practiced medicine in the 1880s and experimented on themselves and others with cocaine's possible therapeutic uses. Freud was interested in it as an antidote for morphine addiction and as treatment for addiction, Halsted saw it as a possible anesthetic. Freud found the drug cured his indigestion, dulled his aches, and relieved his depression. After taking the drug for a few months Freud shifted from his initial focus on neurology to psychology/psychiatry. Halsted became professor of surgery at Johns Hopkins Hospital and devised new and safer surgical techniques - while struggling with his addiction acquired experimenting.

'An Anatomy of Addiction' opens with a laborer being admitted to Bellevue Hospital with a serious compound fracture of the leg. Staff called upon Halsted, their best surgeon, but he had just taken a dose of cocaine. He took one look at the patient and went home to a seven-month cocaine oblivion. Meanwhile, in Europe Freud was using the drug to self-medicate his own anxieties. At the time almost 15% of prescriptions contained cocaine, there were no controlled substances, and addiction was not yet a medical diagnosis. Other users of the day included Ulysses Grant, Queen Victoria, the Shah of Peria, Thomas Edison, and Arthur Conan Doyle (also a physician).

Freud's career goals was to be appointed to a faculty position at the Vienna Medical School, and saw lab experimentation as his preferred means of getting it. His focus on cocaine was initially motivated by a desire to help a friend, Dr. Fleischl-Marxow, addicted to morphine because of the intense, chronic pain created by a non-healing amputation.

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The Theory of Chinese Medicine


The Theory of Chinese Medicine : A Modern Explanation Paperback – June 11, 2014

Author: Visit Amazon's Hai Hong Page | Language: English | ISBN: 1783264489 | Format: PDF, EPUB

The Theory of Chinese Medicine : A Modern Explanation – June 11, 2014
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Review

"This is a book which should not be missed by anyone with an interest in Chinese medicine." -- Donald Gillies, PhD, Emeritus Professor of Philosophy of Science and Mathematics, University College London

"... lucid, brilliant explanation of the terminology and principles of TCM and its approach to the management of syndromes ... This is a book that everyone with even the slightest interest in complementary medicine should read. It does not matter whether one agrees with TCM and accepts the practice. This is a book for understanding." -- Teoh Eng Soon, MBBS, MD, FRCOG, FACS, Gynecologist, former lecturer at NUS Medical School

"The core of the book deals with the epistemological issues concerning the scientific status, in particular the testability, of medical conjectures in Traditional Chinese Medicine. I found it most interesting and challenging, very intelligently written and bringing to bear a great deal of common sense and good philosophy. There is much that is highly original in it." -- Peter J Clark, PhD, Professor of Philosophy, University of St Andrews, UK


Direct download links available for The Theory of Chinese Medicine : A Modern Explanation – June 11, 2014
  • Paperback: 292 pages
  • Publisher: Imperial College Press; 1 edition (June 11, 2014)
  • Language: English
  • ISBN-10: 1783264489
  • ISBN-13: 978-1783264483
  • Product Dimensions: 8.9 x 6.1 x 0.9 inches
  • Shipping Weight: 0.3 ounces (View shipping rates and policies)
  • Amazon Best Sellers Rank: #1,327,643 in Books (See Top 100 in Books)

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The Other Wes Moore: One Name, Two Fates 1st Edition by Moore, Wes published by Spiegel & Grau – January 1, 0010


The Other Wes Moore: One Name, Two Fates 1st (first) Edition by Moore, Wes published by Spiegel & Grau (2010) Hardcover Hardcover – January 1, 0010

Author: | Language: English | ISBN: B00ES29E7G | Format: PDF, EPUB

The Other Wes Moore: One Name, Two Fates 1st Edition by Moore, Wes published by Spiegel & Grau – January 1, 0010
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  • Hardcover
  • Publisher: Spiegel & Grau; 1 edition (0010)
  • ASIN: B00ES29E7G
  • Amazon Best Sellers Rank: #583,226 in Books (See Top 100 in Books)

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Pathophysiology Online for Pathophysiology


Pathophysiology Online for Pathophysiology (User Guide, Access Code and Textbook Package): The Biologic Basis for Disease in Adults and Children, 7e Hardcover – February 18, 2014

Author: Kathryn L. McCance RN PhD | Language: English | ISBN: 0323187358 | Format: PDF, EPUB

Pathophysiology Online for Pathophysiology : The Biologic Basis for Disease in Adults and Children, 7e – February 18, 2014
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  • Hardcover: 1810 pages
  • Publisher: Mosby; 7 edition (February 18, 2014)
  • Language: English
  • ISBN-10: 0323187358
  • ISBN-13: 978-0323187350
  • Product Dimensions: 2.6 x 9 x 11.5 inches
  • Shipping Weight: 8.7 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #104,879 in Books (See Top 100 in Books)
    • #50 in Books > Textbooks > Medicine & Health Sciences > Medicine > Basic Sciences > Pathophysiology
    • #59 in Books > Medical Books > Basic Sciences > Pathophysiology
    • #65 in Books > Textbooks > Medicine & Health Sciences > Medicine > Basic Sciences > Pathology

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Data Monitoring Committees in Clinical Trials


Data Monitoring Committees in Clinical Trials: A Practical Perspective Hardcover – August 30, 2002

Author: Susan S. Ellenberg | Language: English | ISBN: 0471489867 | Format: PDF, EPUB

Data Monitoring Committees in Clinical Trials: A Practical Perspective – August 30, 2002
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Review

"…essential reading for anyone establishing, joining or interacting with data monitoring committees…" (Journal of Clinical Research Practices, September 2007)

"...meets an important need...of interest to the broad spectrum of individuals ivolved in clinical trials..." (Controlled Clinical Trials)

"This wonderful addition to Wiley's 'Statistics in Practice' series is the definitive how-to-do-it manual for running a DMC.." (IRB: Ethics & Human Research , January/February 2003)

"…This is the sort of book that RECs need access to for reference…" (Bulletin of Medical Ethics, February 2003)

"…an excellent starting point …for anyone involved in setting up a data monitoring committee for a clinical trial…" (Short Book Reviews, April 2003)

"…an extremely useful addition…highly recommended…" (Statistical Methods in Medical Research, Vol.12, No.2, 2003)

"...highly recommended, perhaps even required, for those on DMC's...a book well written. I recommend it for library purchase." (The Statistician)

"......clearly required reading for scientists working on clinical trials..." (Good Clinical Practice Journal, Dec 2003)

"...would recommend it to any statistician in the pharmaceutical industry who has any dealing with DMCs..." (Pharmaceutical Statistics, Vol 2, 2003)

"There is very little to criticize about this book…[it] is well written, addressing philosophical, statistical and practical issues…" (Statistics in Medicine, 2004; 23)

“…well organized…invites the reader to go on…” (Statistical Methods in Medical Research, No.13 2004) 

From the Back Cover

There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities.
* Provides a practical overview of data monitoring in clinical trials.

* Describes the purpose, responsibilities and operation of data monitoring committees.

* Provides directly applicable advice for those managing and conducting clinical trials, and those serving on data monitoring committees.

* Gives insight into clinical data monitoring to those sitting on regulatory and ethical committees.

* Discusses issues pertinent to those working in clinical trials in both the US and Europe.
The practical guidance provided by this book will be of use to professionals working in and/or managing clinical trials, in academic, government and industry settings, particularly medical statisticians, clinicians, trial co-ordinators, and those working in regulatory affairs and bioethics.

Direct download links available for Data Monitoring Committees in Clinical Trials: A Practical Perspective – August 30, 2002
  • Hardcover: 208 pages
  • Publisher: Wiley; 1 edition (August 30, 2002)
  • Language: English
  • ISBN-10: 0471489867
  • ISBN-13: 978-0471489863
  • Product Dimensions: 9.4 x 6.3 x 0.8 inches
  • Shipping Weight: 1.1 pounds (View shipping rates and policies)
  • Amazon Best Sellers Rank: #1,255,439 in Books (See Top 100 in Books)
Introduction


Responsibilities of the Data Monitoring Committee and Motivating Illustrations


Composition of a Data Monitoring Committee


Independence of the Data Monitoring Committee: Avoiding Conflicts of Interest


Confidentiality Issues Relating to the Data Monitoring Committee


Data Monitoring Committee Meetings


Data Monitoring Committee Interactions with Other Trial Components or Related Groups


Statistical, Philosophical and Ethical Issues in Data Monitoring


Determining When a Data Monitoring Committee Is Needed


Regulatory Considerations for the Operation of Data Monitoring Committees


Index
Susan Ellenberg is a Professor of Biostatistics at the University of Pennsylvania. Prior to that she played a prominent role in the development of statistical methods for clinical trials at the US Food and Drug Administration. She made major contributions to the Harmonization Committee's ICH Guidelines on statistical methods in clinical trials, particularly the Guideline E9.

Tom Fleming and David DeMets are Professor of Biostatistics at University of Washington and Wisconsin University respectively. They are among the world's leading experts in group sequential methods. Fleming is famous for the O'Brien-Fleming stopping rule that bears his name and DeMets is known for the Lan-DeMets alpha spending function approach to group sequential analysis.

With such experts and excellent writers you get what you should expec t, an authoritative treatment of the practical and technical aspects of the monitoring of data by Data Monitoring Committees (DMCs, previously called Data Safety and Monitoring Boards, DMSBs). These committees look at interim data from a clinical trial to judge whether the trial should be stopped early for safety concerns. In their charter they can set-up their own rule or can debate and make subjective decisions. These authors through their experience present examples and also formal statistical methods that can be used not only to stop for safety concerns but also to stop if safety and efficacy are demonstrated earlier than anticipated in the design. Also if the trial is clearly going to be unsuccessful they can stop for futility as well.

The development of group sequential methods and adaptive designs make a formal analysis for the DMC possible. For a detailed account of group sequential methods see the book by Jennison and Turnbull.

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